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Chlamydia pneumoniae has been proposed as a possible link to an infectious etiology of MS.1,2⇓ An article in this issue of Neurology by Yao et al. supports this hypothesis; the investigators conclude that the oligoclonal bands in CSF of patients with MS represent antibodies against Chlamydophilaantigens.3 This finding could be exciting, but readers are urged to exercise caution in their interpretation of these findings.
MS is a complex demyelinating disease of unknown etiology with a prevalence of up to 350,000 cases in the United States annually.4 An infectious etiology has been supported by epidemiologic studies, studies in identical twins, and studies indicating an increase in IgG levels in CSF in patients with MS.4 The possible association of chlamydia with MS, first reviewed by Perlmutter and Darvish in 1983 and more recently by …
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