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February 13, 2001; 56 (3) Brief Communications

Clinical trials in HIV-associated cognitive impairment: Cognitive and functional outcomes

G. Schifitto, K. Kieburtz, M.P. McDermott, J. McArthur, K. Marder, N. Sacktor, D. Palumbo, O. Selnes, Y. Stern, L. Epstein, S. Albert
First published February 13, 2001, DOI: https://doi.org/10.1212/WNL.56.3.415
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Abstract

Cognitive and functional outcomes are of primary interest in the design of efficacy trials in HIV-associated cognitive impairment. In a longitudinal cohort study, weak associations were found between measures of cognitive performance and commonly used measures of daily functioning (mostly self-report measures) in HIV-infected individuals. Modifications of current functional scales or new functional instruments are needed to assess the clinical relevance of cognitive changes in clinical trials of HIV-associated cognitive impairment.

  • Received June 22, 2000.
  • Accepted October 29, 2000.
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