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Cerebral palsy (CP) is a common neurologic disorder affecting approximately 2 in every 1,000 children. CP is not a single disease entity. Rather, the term denotes a heterogeneous collection of clinical syndromes characterized by abnormal control of movement or posture, early onset, and the absence of any recognizable underlying progressive disorder. The constellation of symptoms in children with CP varies greatly, depending on the child’s specific motor difficulties, parts of the body involved, and the presence of associated impairments such as seizures, abnormal vision or hearing, language delays, and cognitive and behavior problems. CP develops as a consequence of damage to the developing brain and results from a number of different causes, most of which are thought to be of prenatal origin or associated with prematurity and very low birth weight (VLBW). 1,2⇓ Premature and VLBW infants are 10 to 15 times more likely to develop CP than term babies.
Periventricular leukomalacia (PVL) is the most common neuropathologic lesion found in premature infants who develop CP. PVL is …
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