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Abstract
Article abstract The definitive diagnosis of Creutzfeldt–Jakob disease (CJD) requires brain tissue analysis. A positive assay for the 14-3-3 protein in CSF has been suggested to be highly sensitive and specific in patients with CJD. The authors describe three patients for whom CSF 14-3-3 assays were falsely positive or falsely negative. Caution against overreliance on this putative biomarker is suggested in the diagnosis of CJD.
- Received April 3, 2000.
- Accepted July 19, 2000.
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