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Multifocal motor neuropathy (MMN) is a potentially treatable disorder characterized by slowly progressive, asymmetric, predominantly distal limb weakness, without documented sensory impairment. The patients have multifocal persistent partial conduction blocks in motor but not in sensory nerves.1 MMN is a chronic disease without documented spontaneous remissions. The cause of MMN is not known, but an immune-mediated nature is suspected mainly because 1) the presence of conduction blocks parallels characteristics of the motor form of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), 2) immunomodulating treatment may result in improvement, and 3) many patients have immunoglobulin M (IgM) antibodies to the ganglioside GM1. MMN must be differentiated from other lower motor neuron syndromes, in particular the adult form of progressive spinal muscular atrophy. Electromyography (EMG) and CSF examination help to distinguish MMN from …
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