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The only specific therapies we currently have for stroke management are medical methods to prevent inappropriate coagulation, surgical procedures for repair of vascular abnormalities, and thrombolytic therapy. Despite considerable effort, no neuroprotective agents have been proven to be effective for patient care. To date, relatively little attention has been devoted to developing methods for the restoration of function.
In this issue of Neurology, Kondziolka et al.1 report the results of a limited phase I study in which they transplanted cultured human neurons into the brains of stroke victims. Their ultimate goal is to restore neurologic function, and it is conceivable that such techniques could produce some degree of recovery, possibly even years after a stroke. What a remarkable achievement that would be!
The authors report that, using stereotaxic surgery, they were able to insert LBS-Neurons derived from the NT2/D1 human precursor cell …
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