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To the Editor:
The brief communication by Weber et al.1 provides interesting comparative in vitro antiviral bioactivity data of the two forms of beta interferons (IFNβ): 1a and 1b. The IFNβ-1a product tested is not used clinically and no data are presented comparing either of the two clinically approved forms of IFNβ-1a, which makes direct comparison to these products difficult. There also is some uncertainty remaining about the comparison presented.
First, it is well recognized that IFN-specific activity is highly dependent on the nature of the assay employed. The specific cell line, virus used, IFN reference standard tested, and indicator dye are variables that differ among assays. These details would enhance the article …
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