Cognitive and MRI aspects of corticobasal degeneration and progressive supranuclear palsy
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To the Editor:
We read with interest the article on cognitive and MRI aspects of corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) by Soliveri et al.1 They show that cognitive function tests and MRI are beneficial for differentiation between CBD and PSP. We also studied MRI features in 12 patients with clinically diagnosed PSP and 4 patients with CBD. We would like to compare their study with ours and pose several questions.
In our study, age (mean ± SD) was 67.4 ± 5.8 years in PSP and 65.2 ± 8.3 years in CBD. Duration from the clinical onset (mean ± SD) was 3.8 ± 2.2 years in PSP and 3.5 ± 2.3 years in CBD. T1-weighted images revealed midbrain atrophy in all patients with PSP. Proton density images disclosed mild hyperintensity in the periaqueductal region in eight patients with PSP. These MRI findings were not present in …
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