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An understanding of mechanisms involved in normal learning and memory has made possible the evaluation of memory in specific diseases and suggested new treatment approaches. In this issue of Neurology, Barrett et al. studied memory for internally generated material in patients with dementia.1 They examined how coming up with words on one’s own (internally generated) versus experiencing words supplied by the examiner affected memory performance in patients with probable AD and in those with PD with frontal-subcortical dementias (i.e., “Parkinson plus” syndromes). They observed that memory for self-generated items was superior to that for items externally presented for both patient groups. This “generation effect” is a classic finding in the study of memory.2 In the Barrett et al. study, this effect was most notable in recognition for Parkinson plus patients and in incidental recall (i.e., without instructions to remember) for patients with AD. The article illustrates the significance of characterizing memory processes that are sensitive to disruption in dementia, and suggests treatment for optimizing memory performance. Such memory strategies could include creating environments that …
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