Recombinant calcium channel is recognized by Lambert–Eaton myasthenic syndrome antibodies
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Abstract
Article abstract The authors studied sera from 36 patients with Lambert–Eaton myasthenic syndrome (LEMS) by immunoblots using the recombinant protein derived from the DNA sequence encoding for the domain III S5-S6 linker of the P/Q-type voltage-gated calcium channel α1 subunit. The results of 18 patients were positive for antibodies to this recombinant protein. The results of 2 of 10 patients with lung cancer without LEMS were also positive.
- Received June 11, 1999.
- Accepted September 18, 1999.
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