Meningeal metastases from malignant melanoma presenting with gaze-evoked tinnitus
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Gaze-evoked tinnitus (GET) is uncommon and has been reported only in patients operated on for posterior fossa tumors. Reported cases of GET developed shortly after patients underwent surgery and followed complete hearing loss in the patients’ affected ear.1,2 We report a patient who had GET as an early symptom of CNS and meningeal metastases from a malignant melanoma.
Case report.
In March 1994, a 32-year-old woman underwent surgical resection of a cutaneous malignant melanoma of the upper left abdominal wall (Clark II, Breslow 0.4). Axillary nodal metastases were found in June 1997, and radical axillary dissection was performed. Subsequently, she received adjuvant immunotherapy with interferon-alpha. By April 1998, numerous subcutaneous metastatic lesions had been surgically resected.
In April 1998, she had right facial pain (V2 and V3 distribution) and one episode of true vertigo with nausea and vomiting. On neurologic examination, a moderate right neurosensory-type hearing loss was found, and facial sensation and blink reflexes were …
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The functional anatomy of gaze-evoked tinnitus and sustained lateral gazeA.H. Lockwood, D.S. Wack, R.F. Burkard et al.Neurology, February 27, 2001