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Serum IgM antibodies to the ganglioside GM1 are frequently associated with multifocal motor neuropathy (MMN), with a prevalence of 20% to 80% depending on the study and the ELISA technique used.1-5 Even though the diagnostic value of anti-GM1 antibodies in MMN was confirmed in a recent meta-analysis,4 these antibodies are not specific for this disease. They were also found, less frequently, in patients with other immune neuropathies or motor neuron disease (MND).2,3 There is however, a consistent proportion of patients with MMN not bearing these antibodies.2-5 Pestronk et al.6 used a new ELISA technique based on the covalent linkage of GM1 to the secondary amino groups on Covalink ELISA plates (Nunc, Roskilde, Denmark). This revealed the presence of these antibodies in 85% of patients with MMN with an improvement of their specificity for immune-mediated motor neuropathy.
Methods.
We compared the sensitivity, specificity, and positive predictive value4, …
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