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To the Editor: In their interesting article,1 Lopez et al. present data on the association between quantitative spectral EEG and subsequent cognitive and functional decline and survival in patients with probable Alzheimer's disease (AD). The authors report that patients with abnormal EEGs reach the defined endpoints for cognitive function and activities of daily living sooner than patients with normal EEGs. Abnormal EEG results were not related to an increased risk of mortality in these patients. Based on these results, the authors conclude that abnormal EEG results predict disease progression but not physical survival. We have two main methodologic problems with the interpretation of …
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