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Reply from the Authors: We agree with Sudo and Toshiro that B12 deficiency should be considered in patients with various neuropsychiatric disturbances associated with white matter lesions on brain MRI. In our patient with B12 deficiency, along with one previously reported by Chatterjee et al.,2 white matter hyperintensities were observed on brain MRI. In both patients, clinical and radiologic abnormalities partially resolved with hydroxocobalamin replacement therapy. This prompted us to investigate further the frequency and characteristics of pathologic findings on brain MRI in patients with B12 deficiency. …
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