Amelioration of refractory dysesthetic limb pain in multiple sclerosis by gabapentin
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Pain is a well-recognized and disabling symptom in patients with MS. In one large clinical series, 55% of MS patients experienced acute or chronic pain at some time during their illness.1 Chronic neuropathic pain syndromes, which include dysesthetic extremity pain (DEP), painful spasms due to spasticity, and paroxysmal tonic spasms, occur in as many as 48% of patients with MS.1 DEP in MS is particularly difficult to treat. Therapies for chronic DEP include amitriptyline, carbamazepine, phenytoin, and opiates; however, many patients do not receive complete pain relief or cannot tolerate these medications because of adverse effects.1 There is a need for more effective and better tolerated treatment for DEP in patients with MS.
Gabapentin is a novel anticonvulsant agent that is effective as adjunctive therapy for partial seizures.2 There is anecdotal evidence that gabapentin may be helpful in the treatment of …
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