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For patients, as well as for many physicians and scientists who have spent much of their careers trying to understand ALS, the data presented here represent renewed hope for the future. Only a few years ago, the idea that we would be discussing therapeutic advances in June 1995 would have been treated with some skepticism. Clearly, more progress is required before this work can have a significant impact on the progression of ALS. The mix of basic and clinical research presented in this Supplement represents a cross-section of the rapidly increasing momentum in the field of ALS investigation. There is an emerging consensus about pathophysiology-particularly regarding oxidative stress and excitotoxicity-and this offers great promise for the future.
The reviews by Leigh and Meldrum of the impact of excitotoxins in ALS serve to illustrate two …
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