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To the Editor: The working premise that active MS is a measure of an inflammatory response and that beta interferons do take part [3,1] in the resolution of this may be criticized. Among the methods described in these research papers, the first observation concerns comparisons made in the area of disease in MRI scan slices as baseline, and subsequently during the course of the trial as supporting evidence of effect. The assumption here is that area changes are proportional to volume changes and are independent of total CNS size in the inflammatory response. There was a failure to compare the original lesion sizes as an area with the total brain or total cord area of that slice. Also, unfortunately, we were not told the width or number of the slices per patient, the distances between them, nor the changes in overall brain …
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