Is the intracellular pH different from normal in the epileptic focus of patients with temporal lobe epilepsy?: A sup 31 P NMR study

W.-J. Chu; H. P. Hetherington; R. I. Kuzniecky; J. T. Vaughan; D. B. Twieg; R. E. Faught; F. G. Gilliam; J. W. Hugg; G. A. Elgavish

doi:10.1212/WNL.47.3.756

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Abstract

We performed in vivo sup 31 P NMR spectroscopic studies of human brain on a 4.1 T whole-body NMR system. Based on a control group of 20 healthy volunteers, the normal pH_i was 7.05 (SD, 0.06; SEM, 0.01) in the left temporal lobe and 7.04 (SD, 0.04; SEM, 0.01) in the right temporal lobe. We also studied a patient group consisting of 13 individuals with unilateral temporal lobe epilepsy. The mean pH_i was 7.02 (SD, 0.04; SEM, 0.01) in the ipsilateral lobe and 7.02 (SD, 0.05; SEM, 0.01) in the contralateral lobe. These results clearly show that no statistically significant difference in pH_i is observed between the two lobes, either in normal controls or in patients. Also, no significant pH_i difference exists between the control group and the patient group. Lateralization in each of the 13 patients with unilateral epilepsy, based on their individual pH_i difference between the ipsilateral lobe and contralateral lobe (Delta pH_i), showed that three patients were nondiagnostic cases because their Delta pH_i s were not significantly different from zero (<or=to 0.02), five patients showed small Delta pH_i s consistent with their clinical lateralization, whereas the remaining five patients showed Delta pH sub i-based lateralization opposite to the clinical findings. These results seem to indicate an essentially random distribution around Delta pH_i = 0 within a very small experimental error of +/-0.02 pH units. pH_i obtained from eight different areas in each of the 13 unilateral patients also did not show any significantly nonzero Delta pH_i values. These results led to the conclusion that even at the excellent spectral resolution and reproducibility of the 4.1 T machine (typical SD of 0.05 pH units), no significant pH_i effect, induced by temporal lobe epilepsy, could be detected. Therefore, in this study, Delta pH_i does not appear to be a clinically useful tool for the lateralization of epileptic foci in patients with temporal lobe epilepsy.

NEUROLOGY 1996;47: 756-760

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Is the intracellular pH different from normal in the epileptic focus of patients with temporal lobe epilepsy?

A sup 31 P NMR study

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Is the intracellular pH different from normal in the epileptic focus of patients with temporal lobe epilepsy?

A sup 31 P NMR study

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