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To the Editor: The recent paper by Favale et al. [1] on the anticonvulsant effect of fluoxetine in humans reports dramatic positive effects of this drug in patients with resistance to treatment with usual antiepileptic drugs (AEDs).
At the end of the follow-up period, six patients showed a complete disappearance of their daily seizures, while in the others, seizure frequency was lowered by 30%, and none had daily seizures any longer. The study was conducted as an unblinded, openlabel, add-on trial, with a dosage of 20 mg/d in addition to usual treatment. Also, a marked reduction of EEG …
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