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To the Editor: Looking for reliable biochemical markers to estimate brain damage in epilepsy and neurologic diseases, we followed with interest the publications of Rabinowicz et al. [1,2] and DeGiorgio et al. [3] concerning neuron-specific enolase (NSE) in epilepsy. In contrast to the widely accepted value of NSE in CSF to estimate ongoing brain damage, the value of serum NSE (s-NSE) is controversial. [4,5] The recent paper by DeGiorgio et al. [3] stressed the value of s-NSE in status epilepticus. However, their optimistic statement "s-NSE is a promising in vivo marker of brain injury in status epilepticus'' was, to our minds, not proven by the presented results.
1. Eight of the 19 patients had acute …
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