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To the Editor: The article by Kertesz et al [1] reported three cases of primary progressive aphasia (PPA) with pathologic features of Pick's disease. The authors conclude that "PPA is a syndrome whose most common substrate is a variant of Pick's disease."
The nosology of non-Alzheimer type cortical dementia has been recently reviewed, and Pick's disease has been considered a histologic variant of frontotemporal dementia. [2,3] The earliest and most suggestive clinical findings of frontotemporal dementia are behavioral disturbances, affective symptoms, and speech disorder. [3,4] The …
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