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Headaches in a cancer hospital are common and often require extensive diagnostic evaluation to exclude metastatic intracranial disease or infection. However, one does not expect to encounter headache in an individual with no other neurologic illness who donates bone marrow. We have seen two patients develop positional headaches, which were typical of low pressure headaches occurring after lumbar puncture, after bone marrow harvest. In both patients, the headaches resolved without specific therapy.
Case reports.
Patient 1.
A 44-year-old woman underwent elective bone marrow harvest to provide marrow for an HLA compatible sibling. She was morbidly obese. For several years, she suffered diffuse headache on awakening that would abate as she stood up and began her daily activities. The physician performing the bone marrow harvest noted the patient's obesity obscured the usual landmarks. When the surgical drapes were removed, several puncture marks were noted over the lateral sacrum. When the patient awoke from general anesthesia, she complained of severe …
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