Experimental cerebral ischemia produces platelet aggregates
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Abstract
Human studies indicate that transient platelet abnormalities accompany acute cerebral ischemia. Although these abnormalities may precipitate the ischemic process, ischemia could also alter platelet function. Platelets were therefore studied in gerbils subjected to 1 hour of unilateral carotid artery occlusion. Venous blood from five clinically affected gerbils contained more aggregated platelets (37.8% ± 6.4) than did blood from eight unaffected animals (11.1% ± 3 .0; p <0.01). Platelets labeled with 3H-serotonin were increased in ishcemic brain; the ratio of radioactivity in the ipsilateral versus contralateral hemisphere was greater in eight dected (1.09 f 0.03) than in 19 unaffected (1.00 ± 0.01; p <0.02) animals. The radioactive serotonin was located predominantly within blood vessels. Cerebral ischemia thus stimulated the formation of platelet aggregates, a response which could contribute to the ischemic process.
- © 1979 by the American Academy of Neurology
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