作者@article {Flanagan2089 ={密纹唱片Flanagan和a .麦肯和退役军人列侬和j·卡恩斯和伞齿轮Weinshenker K.N. Krecke和m . Matiello B.M.基冈和b . Mokri A.J. Aksamit中华民国Pittock},标题={多种的孤立的脊髓病},体积={76}={24},页面= {2089 - 2095}= {2011},doi = {10.1212 / WNL。出版商0 b013e31821f468f} = {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:报告的临床表型和结果分离多种的脊髓病。首页方法:我们系统地回顾了临床、血清学和核磁共振数据(女)20日31日病人提供一个孤立的脊髓病与癌症共存:癌(肺、9;乳房,7;肾、2;甲状腺,2;卵巢和子宫内膜,2),黑素瘤(2),或其他癌症(3),或多种自身抗体与强大的癌症协会(amphiphysin {\ textendash}免疫球蛋白G(免疫球蛋白),9;collapsin response-mediator蛋白5 {\ textendash}免疫球蛋白,9;浦肯野细胞胞质自身抗体类型1、2;antineuronal核自身抗体(安娜){\ textendash} 1, 1; ANNA-3, 1). Results: Of 31 patients who presented with a progressive myelopathy, symptom onset was subacute in 16 (52\%). The median age was 62 years. CSF abnormalities included elevated protein (\>45 mg/dL), 22; pleocytosis, 15; excess oligoclonal bands (normal \<4), 7. MRI cord abnormalities identified in 20 patients were longitudinally extensive (\>3 vertebral segments), 14; symmetric tract or gray matter{\textendash}specific signal abnormality, 15 (enhancing in 13). Myelopathy preceded cancer diagnosis in 18 patients (median interval 12 months; range 2{\textendash}44). After myelopathy onset, 26 patients underwent oncologic treatment, immunosuppressive treatment (median delay to commencing immunotherapy 9.5 months [range 1{\textendash}54]), or both; only 8 improved (31\%). At last neurologic evaluation (median interval after onset 17 months; range 1{\textendash}165 months), 16 patients (52\%) were wheelchair-dependent (median time from onset to wheelchair 9 months [range 1{\textendash}21]). Ten patients died after a median of 38 months from symptom onset (range 7{\textendash}152). Conclusion: Symmetric, longitudinally extensive tract or gray matter{\textendash}specific changes on spinal MRI should raise suspicion for a paraneoplastic myelopathy. Resulting disability is often severe. Only a minority of patients improve with treatment.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/76/24/2089}, eprint = {//www.ez-admanager.com/content/76/24/2089.full.pdf}, journal = {Neurology} }