TY - MRI的T1 -急性炎症的证据leukocortical病变早期的多发性硬化症患者的JF -神经学乔-神经病学SP - 714 LP - 721 - 10.1212 / WNL。首页0000000000004227六世- 89 - 7盟Josefina Maranzano AU -大卫·a·Rudko盟国中村AU -斯图亚特·库克AU -迭戈Cadavid AU -狮子座Wolansky AU -道格拉斯·l·阿诺德盟Sridar Narayanan Y1 - 2017/08/15 UR - //www.ez-admanager.com/content/89/7/714.abstract N2 -目的:钆增强病变识别影响患者首页早期皮质的多发性硬化症(MS)和描述这些病变的频率和演化。方法:回顾性观察,纵向分析核磁共振扫描收集的一部分Betaseron vs Copaxone在多发性硬化三剂量钆和3 t MRI端点(成为)的研究。七十五例早期女士每月进行扫描,在12 - 24个月,使用后3 t MRI三剂量钆。总共1188扫描被包括在分析中。总共有139人选择使用管道算法集成的图像信息从大脑皮层灰质钆增强病变口罩和面罩。这些扫描钆增强病变进行评估来确定影响大脑皮层。结果:钆增强病变的总数是2044。钆增强病变的数量影响大脑皮层是120年(6%),其中95%是leukocortical。钆增强病变患者的数量显示影响大脑皮层27岁(36%)。钆增强病变的数量影响大脑皮层在基线是25(21%)和开发一些新的病变在后续扫描49 (41%)。持久的病变的数量46 (38%)。Conclusions: The presence of enhancing lesions affecting the cortex and adjacent white matter, although transient and not frequent, suggests that at least some cortical lesions are related to blood–brain barrier disruption. Our data support the concept that there may be an acute inflammatory phase in the development of leukocortical MS lesions.Clinicaltrials.gov identifier: NCT00176592.BBB=blood–brain barrier; BECOME=Betaseron vs Copaxone in Multiple Sclerosis with Triple-Dose Gadolinium and 3T MRI Endpoints; CIS=clinically isolated syndrome; CL=cortical lesion; FLAIR=fluid-attenuated inversion recovery; GM=gray matter; ICBM=International Consortium for Brain Mapping; MS=multiple sclerosis; RRMS=relapsing-remitting multiple sclerosis; TE=echo time; TI=inversion time; TR=repetition time; WM=white matter ER -