PT -期刊文章盟Josefina Maranzano AU -大卫·a·Rudko盟国中村AU -斯图亚特·库克AU -迭戈Cadavid AU -狮子座Wolansky AU -道格拉斯·l·阿诺德盟Sridar Narayanan TI - MRI leukocortical病变患者的急性炎症的证据- 10.1212 / WNL多发性硬化症早期援助。0000000000004227 DP - 2017年8月15日TA -神经病首页学第六PG - 714 - 721 - 89 IP - 7 4099 - //www.ez-admanager.com/content/89/7/714.short 4100 - //www.ez-admanager.com/content/89/7/714.full所以Neurology2017 8月15日;钆增强病变89 AB -目的:识别影响患者早期皮质的多发性硬化症(MS)和描述这些病变的频率和演化。方法:回顾性观察,纵向分析核磁共振扫描收集的一部分Betaseron vs Copaxone在多发性硬化三剂量钆和3 t MRI端点(成为)的研究。七十五例早期女士每月进行扫描,在12 - 24个月,使用后3 t MRI三剂量钆。总共1188扫描被包括在分析中。总共有139人选择使用管道算法集成的图像信息从大脑皮层灰质钆增强病变口罩和面罩。这些扫描钆增强病变进行评估来确定影响大脑皮层。结果:钆增强病变的总数是2044。钆增强病变的数量影响大脑皮层是120年(6%),其中95%是leukocortical。钆增强病变患者的数量显示影响大脑皮层27岁(36%)。钆增强病变的数量影响大脑皮层在基线是25(21%)和开发一些新的病变在后续扫描49 (41%)。 The number of persistent lesions was 46 (38%).Conclusions: The presence of enhancing lesions affecting the cortex and adjacent white matter, although transient and not frequent, suggests that at least some cortical lesions are related to blood–brain barrier disruption. Our data support the concept that there may be an acute inflammatory phase in the development of leukocortical MS lesions.Clinicaltrials.gov identifier: NCT00176592.BBB=blood–brain barrier; BECOME=Betaseron vs Copaxone in Multiple Sclerosis with Triple-Dose Gadolinium and 3T MRI Endpoints; CIS=clinically isolated syndrome; CL=cortical lesion; FLAIR=fluid-attenuated inversion recovery; GM=gray matter; ICBM=International Consortium for Brain Mapping; MS=multiple sclerosis; RRMS=relapsing-remitting multiple sclerosis; TE=echo time; TI=inversion time; TR=repetition time; WM=white matter