RT期刊文章SR电子T1 Florbetapir成像在脑淀粉样angiopathy-related出血摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 697 OP 704 10.1首页212 / WNL。89签证官0000000000004228是7 A1尼古拉斯Raposo A1梅勒妮Planton A1帕特里斯Peran A1皮埃尔Payoux A1法布里斯博纳维尔A1艾莎Lyoubi A1 Jean Francois Albucher A1 Blandine Acket A1安妮苏菲Salabert A1 Jean Marc Olivot A1安妮Hitzel A1弗朗索瓦Chollet A1杰雷米Pariente年2017 UL //www.ez-admanager.com/content/89/7/697.abstract AB目的:评估是否18 f-florbetapir,宠物淀粉首页指示剂,可以结合血管淀粉样蛋白在脑淀粉样血管病(CAA)通过比较皮质florbetapir保留患者的急性期期间CAA-related大叶性脑出血患者(我)和hypertension-related深的我。方法:急性CAA-related患者患者大叶性我是前瞻性的,相比之下,深的我。18 f-florbetapir宠物,大脑核磁共振,所有参与者均获得APOE基因型。皮质florbetapir标准摄入值比率(SUVr)计算整个小脑作为参考。CAA患者和那些与我比较深的意思是皮质florbetapir SUVr值。结果:15例急性肺叶的波士顿我完成修改后的标准可能的创新艺人经纪公司(平均年龄12年= 67±)和18例急性深我(平均年龄= 63±11年)登记。全球平均皮质florbetapir SUVr明显高于患者CAA-related我比患者深我(1.27±0.12 vs 1.12±0.12, p = 0.001)。皮质florbetapir SUVr分化CAA-ICH患者从那些深我(曲线下的面积= 0.811;95%可信区间[CI] 0.642 - -0.980)的敏感性为0.733 (95% CI 0.475 - -0.893)和0.833 (95% CI 0.598 - -0.948)的特异性。结论:皮质florbetapir吸收增加患者CAA-related我相对于那些深的我。虽然18 f-florbetapir宠物可以标签血管β-amyloid和作为一个结果标志在以后的临床试验,其诊断价值在急性CAA-related我似乎在临床practice.Aβ=β-amyloid有限; AD=Alzheimer disease; CAA=cerebral amyloid angiopathy; CI=confidence interval; CMB=cerebral microbleed; cSS=cortical superficial siderosis; FLAIR=fluid-attenuated inversion recovery; GRE=gradient recalled echo; ICH=intracerebral hemorrhage; IQCODE=Informant Questionnaire on Cognitive Decline in the Elderly; PiB=Pittsburgh compound B; ROI=region of interest; STRIVE=Standards for Reporting Vascular Changes on Neuroimaging; SUV=standardized uptake value; SUVr=standardized uptake value ratio; WMH=white matter hyperintensities