RT期刊文章SR电子T1晚发性抑郁症状增加痴呆的风险在小血管疾病摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 1102 1109 10.1212 / WNL OP。首页87签证官0000000000003089 11 A1 Ingeborg高家俊van Uden A1海伦娜·m·范德霍尔斯特A1以斯帖贝拉van Leijsen A1 Anil m . Tuladhar A1 Anouk G.W.范诺登A1 Karlijn f . de Laat A1 Jurgen A.H.R. Claassen A1 Ewoud j·冯·罗伊A1 pc kessel A1江户理查德A1英迪拉Tendolkar A1 Frank-Erik de Leeuw年2016 UL //www.ez-admanager.com/content/87/11/1102.abstract AB目的:前瞻性研究抑郁症状的作用(DS)全首页因痴呆与小血管疾病在人群中(计算),考虑到DS发病年龄和认知能力。内梅亨大学奈梅亨方法:运行DMC研究(扩散张量磁共振队列)是一个前瞻性群组研究503名老年人与圣言在MRI无痴呆基线(2006),随访5年(2012年)。相比kaplan - meier DS和痴呆风险的曲线分层使用生存率较。我们使用Cox回归分析计算风险比率。结果:随访可供496名参与者(平均65.6岁基线(标准差8.8);平均随访时间5.2年)。全因痴呆了41名参与者。5.5年期痴呆风险较高的那些DS(风险比为2.7,95%置信区间1.4 - -5.2),独立于混杂因素。这是由那些晚DS。五年累计痴呆的风险差异是高参与者与抑郁症状有很高的基线认知能力(不DS 0.0% vs DS 6.9%, log-rank p < 0.001),而与那些认知能力低的基线。结论:晚发性DS增加痴呆风险,独立于圣言。 Especially in those with relatively high cognitive performance, DS indicate a higher risk. In contrast to current practice, clinicians should monitor those with DS who also show relatively good cognitive test scores.CES-D=Center for Epidemiologic Studies Depression Scale; CI=confidence interval; DS=depressive symptoms; DSM-IV=Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition); EODS=early-onset depressive symptoms; GM=gray matter; HR=hazard ratio; LODS=late-onset depressive symptoms; MMSE=Mini-Mental State Examination; MPRAGE=magnetization-prepared rapid-acquisition gradient echo; RUN DMC=Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort; SAT=speed–accuracy trade-off; SVD=small vessel disease; TBV=total brain volume; WM=white matter; WMH=white matter hyperintensity

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