TY - T1的可分离的基质构成抽象和具体名词(P5.193)生产的JF -神经学乔-神经学六世- 86 - 16补充SP - P5.193盟Katheryn兄弟盟-沙龙灰盟穆雷格罗斯曼Y1 - 2016/04/0首页5 UR - //www.ez-admanager.com/content/86/16_Supplement/P5.193.abstract N2 -目的:检查生产的抽象和具体名词在神经退行性疾病患者使用Cookie盗窃图片描述。背景:在先前的研究中,我们观察到双游离在抽象和具体词汇知识之间的语义变体原发性进行性失语(svPPA)和额颞叶痴呆的行为变异(bvFTD)。与健康对照组相比,bvFTD患者更多的损害比具体名词、抽象名词和他们可怜的抽象知识相关的额下回的萎缩。相比之下,svPPA患者更受损的具体名词和抽象名词相比,与左颞叶萎缩有关。在这项研究中,我们测试相同的神经区域是有效的抽象和具体的关键字的理解也在抽象和具体的生产中发挥作用的话。设计/方法:我们评估生产的抽象和具体名词42 bvFTD和21 svPPA病人使用Cookie盗窃的口头描述图片。Patients met published diagnostic criteria, and concreteness or abstractness of each word was calculated using Brysbaert concreteness ratings (Brysbaert, Warriner & Kuperman, 2014). RESULTS: We observe the same double dissociation pattern during production as we previously saw with comprehension: bvFTD patients produce a smaller proportion of abstract nouns than svPPA patients. Moreover, the average concreteness rating for all nouns produced by svPPA patients is lower than for bvFTD. Regression analyses demonstrated that decreased abstract noun production in bvFTD relates to atrophy in the left inferior frontal gyrus. In addition, decreased concrete noun production in svPPA relates to atrophy in the left inferior temporal lobe. CONCLUSIONS: These results corroborate the finding that abstract and concrete nouns are represented in partially dissociable anatomic regions.Disclosure: Dr. Cousins has nothing to disclose. Dr. Ash has nothing to disclose. Dr. Grossman has received personal compensation for activities with GE Whitney Symposium as an invited speaker. Dr. Grossman has received personal compensation in an editorial capacity for Neurology.Wednesday, April 20 2016, 8:30 am-7:00 pm ER -