首页TY - JOUR T1 - Brain Tissue Sodium Concentration in Clinically Isolated Syndrome (S41.007) JF - Neurology JO - Neurology VL - 86 IS - 16 Supplement SP - S41.007 AU - Niamh Cawley AU - Bhavana Solanky AU - Ferran Prados AU - Sara Collorone AU - Sebastian Ourselin AU - Claudia Gandini Wheeler – Kingshott AU - Ahmed Toosy AU - David Miller AU - Alan Thompson AU - Olga Ciccarelli Y1 - 2016/04/05 UR - //www.ez-admanager.com/content/86/16_Supplement/S41.007.abstract N2 - Background: Increased total sodium concentration, which may reflect neurodegeneration, has been demonstrated in the brain of patients with relapsing remitting, secondary progressive and primary progressive multiple sclerosis (MS).然而,尚不清楚的是,在显示临床隔离综合症(CIS)的主体中是否看到加钠目标:本研究的目的是估计正常白物、皮层灰物、深灰物和T2损伤方法:我们招聘16个CIS科目(8F:8M),平均33.5(+7.3)年限从症候发起3个月内和10健康控件(6F:4M)平均34.20岁病人EDSS中位值1.0(范围1.0-2.0)5个CIS主体基点有异常MRI量化总计MRI钠使用3T扫描机在所有科目上执行线性回归模型用于比较按年龄和性别调整的群组间差异结果:T2损耗显示钠浓度提高,而CIS主体为正常白质(452mM++8322mM对351mM++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++常见白质(351mm+2mm+32.5m+058p=0.058bial灰质454mM+4.0m+424mM+2.7mmb+0结论:尽管小组别(招聘正在进行中),本研究扩展MS中钠浓度提高发现范围至CIS增加总钠水平可用作神经轴机能失灵生物标志Cawley没什么可透露博士Solanky没什么可透露博士Prados没什么可透露博士科洛龙没什么可透露博士ourselin没有什么披露博士Gandini Wheeler-Kingshart没有什么可透露的博士Toosy因生物元Ide活动获得个人补偿博士米勒没有什么披露博士Thompson没什么可透露博士Ciccarelli因与Novartis公司、Biogen公司和GE公司作为顾问开展的活动而获得个人补偿

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