@article {DahanP5.138作者= {Ariel Dahan罗素戴尔和Fabienne Brilot安德鲁·科恩伯格和艾比。姚},title = {Neuromyelitis视谱系障碍(NMOSD)和AQP4-IgG澳大利亚儿童髓鞘脱失队列(P5.138)},体积={86}={16}补充数量,elocation-id = {P5.138} ={2016},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:描述的临床特征和频率视Neuromyelitis谱系障碍(NMOSD)和aquaporin-4免疫球蛋白(AQP4-IgG)血清阳性的澳大利亚儿童中枢神经系统脱髓鞘疾病的患者群。首页背景:NMOSD最近修订的诊断标准,包括考虑儿童人群。儿童NMOSD并不常见,通常为AQP-IgG血清反应阴性的。此外,尽管许多儿童单相纵向横向脊髓炎有广泛的脊髓病变,AQP4-IgG很少是积极的。方法:我们进行了一项回顾性队列研究的67名儿童向皇家儿童医院,墨尔本,澳大利亚,收购了中枢神经系统脱髓鞘疾病在2007年和2014年之间。所有患者检测AQP4-IgG血清阳性。结果:18岁的孩子(27 [percnt])急性播散性脑脊髓炎(ADEM;六个多相ADEM), 18 (27 [percnt])视神经炎(;四个复发),17 (25 [percnt])横向脊髓炎(TM);一个周期性TM)和9 (13 [percnt])多发性硬化症。 Five children (7[percnt]), aged between six and 15 years, met criteria for NMOSD. Only one child was seropositive for AQP4-IgG, and had a relapsing disease course with mild residual deficits. Of the remaining four children with AQP4-IgG negative NMOSD, three had a monophasic course and one had a relapsing course at latest follow-up. Two children with NMOSD were tested for anti-myelin oligodendrocyte glycoprotein (anti-MOG) antibody and both were seropositive. Conclusions: In this single centre Australian cohort of children with demyelinating CNS disorders, NMOSD represented 7[percnt] of all cases, and only one child was AQP4-IgG seropositive. These findings support those of previous studies, demonstrating that NMOSD is uncommon in children, and that AQP4-IgG seropositivity is rare in children presenting with CNS demyelination overall. Study Supported by: EMY and RCD are supported by National Health and Medical Research Council of Australia fellowships. RCD and FB are supported by funds from MS Research Australia.Disclosure: Dr. Dahan has nothing to disclose. Dr. Dale has nothing to disclose. Dr. Brilot-Turville has received research support from Star Scientic Foundation, Trish MS Research Foundation, MSRA, MS Angels Melbourne, NHMRC, and the Petre Foundation. Dr. Kornberg has nothing to disclose. Dr. Yiu has nothing to disclose.Wednesday, April 20 2016, 8:30 am-7:00 pm}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/86/16_Supplement/P5.138}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }