RT期刊文章SR电子T1室hyperintensities与升高脑淀粉样摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 535 OP 543 10.1212 / WNL。首页86签证官0000000000002352是6 A1迈克尔Marnane A1奥萨马o . Al-Jawadi A1 Shervin Mortazavi A1凯瑟琳·j·Pogorzelec A1 Bing魏王A1霍华德·h·费尔德曼A1 Ging-Yuek r .胸A1的阿尔茨海默病的神经影像学年2016 UL //www.ez-admanager.com/content/86/6/535.abstract AB目的:探讨之间的关系室周的白色板牙hyperintensities (PVWMH)和生首页物标志物升高脑β-amyloid (Aβ)阿尔茨海默病的神经影像学,大型前瞻性多中心观察研究。方法:负担的额、顶叶和枕PVWMH 3 t fluid-attenuated反转恢复MRI在698年评估认知正常受试者和参与者患有轻度认知障碍(MCI)使用一种新颖的半定量的视觉评定量表。结果与CSF-Aβ、florbetapir-PET和氟脱氧葡萄糖(FDG) pet。结果:增加负担,顶叶、枕叶和额PVWMH与升高脑淀粉样就是高florbetapir-PET信号(p < 0.01)和低CSF-Aβ(p < 0.01)。在逻辑回归模型,包括PVWMH、年龄、性别、APOE状态,血管危险因素,脉冲压力,血管二级预防药物,教育、种族、种族、顶叶、枕叶和额PVWMH负担是独立与高florbetapir-PET吸收(p < 0.05)。在类似的逻辑回归模型中,顶叶和枕(p < 0.05),但不是额(p = 0.05) PVWMH与CSF-Aβ独立相关。弱关联之间被发现parieto-occipital PVWMH和CSF-tau升高(p < 0.05)和枕PVWMH和CSF-phospho-tau升高(p < 0.05)。PVWMH与脑代谢减退有关正独立CSF-Aβ水平(p < 0.05)。绝对和组内相关系数的一致性协议,分别为0.83和0.83额叶,顶叶的0.78和0.8,0.45和0.75为枕PVWMH测量。结论:增加PVWMH与脑淀粉样蛋白升高有关独立的潜在混杂因素如年龄、APOE基因型和血管危险因素。PVWMH和脑淀粉样蛋白之间的关系的机制仍有待clarified.Aβ=β-amyloid; AD=Alzheimer disease; ADNI=Alzheimer's Disease Neuroimaging Initiative; CAA=cerebral amyloid angiopathy; CI=confidence interval; CMB=cerebral microbleed; FDG=fluorodeoxyglucose; FLAIR=fluid-attenuated inversion recovery; ICC=intraclass correlation coefficient; MCI=mild cognitive impairment; NC=normal cognition; NINCDS-ADRDA=National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer's Disease and Related Disorders Association; OR=odds ratio; PVWMH=periventricular white matter hyperintensities; ROI=region of interest; SVD=small vessel disease; volTWMH=volumetric measurements of total white matter hyperintensity burden; WMH=white matter hyperintensity