TY - T1的相关性的内皮一氧化氮Sintase,弹性蛋白和Endoglin基因变异在家族性颅内动脉瘤(P01.025) JF -神经学乔-神经病学SP - P01.025 LP - P01.025六世- 78 - 1补充非盟-米歇尔·格雷戈里奥盟Marcela奥古斯塔Pinhel盟- Grei首页ciane玛丽亚Florim盟吉赛尔·苏萨盟-马塞洛Nakazone AU -丹尼斯·马丁斯盟赛米亚席尔瓦盟Ariela盟伽马安基丁酸-桑托斯Marcio路易斯盟Jose Roberto Ferraz球场AU -路易斯·菲利普Lauletta盟卢卡斯更Madureira也非盟- Doroteia Souza盟Tognola Y1 - 2012/04/23 UR - //www.ez-admanager.com/content/78/1_Supplement/P01.025.abstract N2 -目的:分析以挪士的影响、民族解放军和ENG多态性和频率的吸烟和酗酒IA患者和他们的家庭。背景颅内动脉瘤(IA)的特点是异常扩张的动脉动脉环。风险因素可以像吸烟和acoholism一样环境,和遗传变异的内皮一氧化氮sintase(以挪士),弹性蛋白(ELN)和endoglin (ENG)。设计/方法:836人分为6组:G1 - 40个人(家庭IA);G2 - 176 (G1家庭);G3 - 113(零星的IA);G4 - 277 (G3家庭);G5 - 104(控制);G6 - 126 (G5的家庭)。多态性分析eNOS-MboI(和T等位基因),ELN-MvaI(和G等位基因)和ENG (Wt我等位基因)是由PCR - RFLP(聚合酶链反应、限制性片段长度多态性)。关于生活方式、吸烟和acoholism问道。显著性水平术; 0.05 was assumed.Results: eNOS-MboI: A more prevalent in G1 (0,93), G2 (0,83), G3 (0,79), G4 (0,89) than G5 (0,61) and G6 (0,75; P<0,0001). A/A genotype more frequent in G1 (86%); G2 (77%) G3 (79%) and G4 (78%), than G5 (26%) and G6 (50%; P<0,0001). ELN-MvaI: similarity between groups (P>0,05). ENG: Wt more prevalent in G5 (0,81) than in G1 (0,61; P=0,01); I more prevalent in G2 (0,30) than G6 (0,19; P=0,003) and in G3 (0,34) than G5 (0,24; P=0,027). Genotypes with at least one allele Wt (-/Wt) more frequent in G5 (89%) than G1 (69%; P=0,009) and in G2 (77%) than G4 (88%; P=0,003). Genotype II prevailed in G2 (22%), rather than G6 (8% P=0,001). Smokers and alcoholics are more prevalent in G1 (79%; 40%, respectively) and G3 (61%; 36%), than G5 (29%; 20%; P<0,05).Conclusions: Presence of allele A (eNOS) and genotype II (ENG) associate with IA, smoking, acoholism. Presence of allele Wt (ENG-BfaI) can be a protective factor for IA.Disclosure: Dr. Gregrio has received research support from S atilde o Paulo State Research Foundation. Dr. Pinhel has received research support from The Research Foundation of Sao Paulo State - FAPESP. Dr. Florim has received research support from Sao Paulo State. Dr. Amorim has received research support from Sao Paulo State. Dr. Nakazone has received research support from the Research Foundation of Sao Paulo State. Dr. Martins has received research support from the Research Foundation of Sao Paulo State. Dr. Silva has received research support from the Research Foundation of Sao Paulo State. Dr. Crestani has research support from Research Foundation of Sao Paulo State. Dr. Santos has received research support from the Research Foundation of Sao Paulo State. Dr. Ferraz Filho has received research support from the Research Foundation of Sao Paulo State. Dr. Lauletta has received research support from The Research Foundation of Sao Paulo State - FAPESP. Dr. Madureira has received research support from Research Foundation of S atilde o Paulo. Dr. Souza has received research support from the Research Foundation of Sao Paulo State. Dr. Tognola has received research support from S atilde o Paulo State Research Foundation.Monday, April 23 2012, 14:00 pm-18:30 pm ER -