% 0期刊文章%一个米歇尔·格雷戈里奥% Marcela奥古斯塔Pinhel % Greiciane玛丽亚Florim %吉赛尔·苏萨%一个丹尼斯·马丁斯Marcelo Nakazone % %一个Ariela赛米亚席尔瓦% %伽马安基丁酸Marcio路易斯桑托斯% Jose Roberto Ferraz球场%更一个路易斯·菲利普Lauletta %也一个卢卡斯Madureira % Doroteia Souza % Tognola % T相关性内皮一氧化氮Sintase,弹性蛋白和Endoglin基因变异在家族性颅内动脉瘤(P01.025) % D J神经病学2012% % P P01.025-P01.025 % V 78% N 1补充% X目的:分析以挪士的影响、民族解放军和ENG多态性和频率的吸烟和酗酒IA患者和他们的家庭。首页背景颅内动脉瘤(IA)的特点是异常扩张的动脉动脉环。风险因素可以像吸烟和acoholism一样环境,和遗传变异的内皮一氧化氮sintase(以挪士),弹性蛋白(ELN)和endoglin (ENG)。设计/方法:836人分为6组:G1 - 40个人(家庭IA);G2 - 176 (G1家庭);G3 - 113(零星的IA);G4 - 277 (G3家庭);G5 - 104(控制);G6 - 126 (G5的家庭)。多态性分析eNOS-MboI(和T等位基因),ELN-MvaI(和G等位基因)和ENG (Wt我等位基因)是由PCR - RFLP(聚合酶链反应、限制性片段长度多态性)。关于生活方式、吸烟和acoholism问道。假定P < 0.05显著性水平。Results: eNOS-MboI: A more prevalent in G1 (0,93), G2 (0,83), G3 (0,79), G4 (0,89) than G5 (0,61) and G6 (0,75; P<0,0001). A/A genotype more frequent in G1 (86%); G2 (77%) G3 (79%) and G4 (78%), than G5 (26%) and G6 (50%; P<0,0001). ELN-MvaI: similarity between groups (P>0,05). ENG: Wt more prevalent in G5 (0,81) than in G1 (0,61; P=0,01); I more prevalent in G2 (0,30) than G6 (0,19; P=0,003) and in G3 (0,34) than G5 (0,24; P=0,027). Genotypes with at least one allele Wt (-/Wt) more frequent in G5 (89%) than G1 (69%; P=0,009) and in G2 (77%) than G4 (88%; P=0,003). Genotype II prevailed in G2 (22%), rather than G6 (8% P=0,001). Smokers and alcoholics are more prevalent in G1 (79%; 40%, respectively) and G3 (61%; 36%), than G5 (29%; 20%; P<0,05).Conclusions: Presence of allele A (eNOS) and genotype II (ENG) associate with IA, smoking, acoholism. Presence of allele Wt (ENG-BfaI) can be a protective factor for IA.Disclosure: Dr. Gregrio has received research support from S atilde o Paulo State Research Foundation. Dr. Pinhel has received research support from The Research Foundation of Sao Paulo State - FAPESP. Dr. Florim has received research support from Sao Paulo State. Dr. Amorim has received research support from Sao Paulo State. Dr. Nakazone has received research support from the Research Foundation of Sao Paulo State. Dr. Martins has received research support from the Research Foundation of Sao Paulo State. Dr. Silva has received research support from the Research Foundation of Sao Paulo State. Dr. Crestani has research support from Research Foundation of Sao Paulo State. Dr. Santos has received research support from the Research Foundation of Sao Paulo State. Dr. Ferraz Filho has received research support from the Research Foundation of Sao Paulo State. Dr. Lauletta has received research support from The Research Foundation of Sao Paulo State - FAPESP. Dr. Madureira has received research support from Research Foundation of S atilde o Paulo. Dr. Souza has received research support from the Research Foundation of Sao Paulo State. Dr. Tognola has received research support from S atilde o Paulo State Research Foundation.Monday, April 23 2012, 14:00 pm-18:30 pm %U