RT期刊文章SR电子T1认知能力和大脑的完整性在多发性硬化症:扩散张量成像研究(P06.112)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP P06.112 OP P06.112 VO 80是7补充A1莎拉Llufriu A1 Eloy Martine首页z-Heras A1 Cuellar Gabilondo A1尤兰达布兰科Morgado A1 Fortea胡安A1 Carles猎鹰A1玛丽亚赛普维达A1 Nuria Bargallo A1 Nuria苍井空A1 Pablo Villoslada A1弗朗西斯克格劳A1艾伯特Saiz年2013 UL //www.ez-admanager.com/content/80/7_Supplement/P06.112.abstract AB目的:我们旨在识别大脑区域微观结构损伤或病变与认知障碍在多发性硬化症(MS)。背景:断开的白质(WM)大片和灰质(GM)损伤可能与认知功能障碍在MS.DESIGN /方法:我们包括67 MS患者和37控制。认知评估病人的Rao电池通过z得分(正火)。结构T1-MPRAGE和所包含的核磁共振扩散张量成像(DTI)。Tract-based空间统计(tbs)和分布分析(VBA)被用来比较DTI值之间的病人和控制和本地化地区DTI分数各向异性(FA)或平均扩散系数(MD)水平与认知z分数正常WM女士(NAWM)和通用汽车在我们相关的z分数通过损伤与损伤可能性概率映射(行分钟)。结果:医学患者显示普遍减少NAWM FA和增加通用MD在几个地区。口头记忆与特定的大片中每一个分测验和地区病人女士:选择性提醒测试(SRT)长期储存与FA胼胝体(CC)、放射冠,后丘脑的辐射,矢状stratrum和扣带回和通用在左角,MD枕,舌、梭状回和颞叶皮层。NAWM SRT长期检索显示类似的发现,而相关性与通用MD是更广泛的(即。海马、左脑岛、角、枕叶和颞叶皮层)。SRT延迟回忆(DR)与足总在CC和MD左距状,舌、海马、丘脑和梭状皮层。视觉记忆与FA博士在CC和后丘脑的辐射。符号位模式测试与NAWM FA普遍存在相关性。行分钟显示室和放射冠区关联SRT长期存储和DR.CONCLUSIONS:通用和WM微观结构有一个对认知的影响,在不同的领域有所不同。 We provide anatomic rendition of pathways implicated in the different processes of declarative verbal memory.Supported by: Partially funded by the Hospital Clinic Emili Letang grant and by the FIS PS09/00259 from the Instituto de Salud Carlos III (Spanish Ministry of Health).Disclosure: Dr. Llufriu has received personal compensation for activities with Merck Serono, Biogen Idec, Teva, and Novartis. Dr. Martinez-Heras has nothing to disclose. Dr. Gabilondo has nothing to disclose. Dr. Blanco Morgado has nothing to disclose. Dr. Fortea has received personal compensation for activities with Esteve and Novartis. Dr. Falcon has nothing to disclose. Dr. Sepulveda has nothing to disclose. Dr. Bargallo has nothing to disclose. Dr. Sola has nothing to disclose. Dr. Villoslada has received personal compensation for activities with Heidelberg Engineering, Novartis, Roche, Digna Biotech, Neurotec Pharma, and Bionure Pharma. Dr. Villoslada received research support from Novartis, Roche and Digna Biotech. Dr. Graus has nothing to disclose. Dr. Saiz has received personal compensation for activities with Bayer-Schering, Merck-Serono, Biogen Idec, Sanofi-Aventis, Teva Pharmaceutical Industries Ltd and Novartis as consultant and speaker.Thursday, March 21 2013, 7:30 am-12:00 pm