RT期刊文章SR电子T1 Agrammatic帕金森症和原发性进行性失语(P02.047)摩根富林明Logopenic变异神经病学神经学乔FD Lippincott Williams &威尔金斯SP P02.047 OP P02.047 VO 78是1补充A1乔纳森G首页raff-Radford A1约瑟夫·达菲A1 Edythe链A1基思·约瑟夫年2012 UL //www.ez-admanager.com/content/78/1_Supplement/P02.047.abstract AB目的:比较两个变量的帕金森病程度原发性进行性失语(PPA)。背景PPA这个词意味着神经退行性疾病,其特征是失语症、缺乏早期认知障碍。三个变体都承认,PPA-agrammatic PPA-semantic PPA-logopenic,与每个变体的语言障碍的不同模式。很少有研究评估帕金森病在PPA变体。设计/方法:评价帕金森病运动障碍的完工Society-sponsored统一帕金森病评定量表的修订前瞻性招募PPA科目。所有受试者诊断通过语言病理学家之间的共识和神经学家。在与Mann-Whitney U测试组进行比较。结果:23 PPA受试者被诊断出患有PPA-logopenic (n = 11)或PPA-agrammatic (n = 12)。在疾病持续时间没有明显差异(PPA-agrammatic = 3.4年;PPA-logopenic = 3.3年)或发病年龄(PPA-agrammatic = 67.3;PPA-logopenic = 62.0),但这些细微精神状态检查与PPA-logopenic更认知障碍(21.7/30分与26.1/30; p=0.04). Results showed those with PPA-logopenic had fewer parkinsonian features than PPA-agrammatic (5.7/130 vs. 16.8/130; p = 0.003) which was mainly driven by bradykinesia (p=0.02) and rigidity (p=0.06), but not by gait and posture, or tremor.Conclusions: PPA-agrammatic subjects have more parkinsonian features than PPA-logopenic subjects when matched for disease duration. Given worse cognitive scores in the PPA-logopenic subjects, our results are unlikely driven by disease severity. Instead, the findings most likely reflect underlying tau pathologies in PPA-agrammatic subjects as opposed to Alzheimer's disease in the PPA-logopenic subjects.Supported by: Dr. Josephs is funded by NIH R01-DC010367 (PI), R01-AG037491 (PI), R21-AG38736 (Co-I), and the Dana Foundation (PI).Disclosure: Dr. Graff-Radford has nothing to disclose. Dr. Duffy has received personal compensation for activities with Mosby Elsevier. Dr. Strand has nothing to disclose. Dr. Josephs has nothing to disclose.Tuesday, April 24 2012, 07:30 am-12:00 pm