TY - T1的职业特点和模式作为帕金森病的危险因素(P07.133) JF -神经学乔-神经病学SP - P07.133 LP - P07.133六世- 78 - 1补充AU -艾米·伯伦斯坦AU -凯利沙利文盟-魏王盟特首页蕾莎Zesiewicz AU - h . Brownlee盟詹姆斯·莫蒂默Y1 - 2012/04/26 UR - //www.ez-admanager.com/content/78/1_Supplement/P07.133.abstract N2 -目的:评估的角色个性的职业选择和就业模式在帕金森病(PD)的风险。背景PD在某些领域与就业有关。大多数职业研究集中在有毒暴露的潜在因果解释这些关联。然而,PD也与性格特征包括有关减少冒险,寻求新奇,可能影响职业选择和模式。设计/方法:面对面的采访进行了评估职业历史和刚成年的个性指标89 PD病人和99个对照组招募从学术医疗诊所。物流回归控制了年龄、性别和教育研究协会之间的职业特点、个性和患帕金森病的风险。结果:PD例有更少的工作比控制在他们的一生中(平均数±标准差为例= 4.38±2.20;平均数±标准差控制= 5.00±2.26;p = 0.03)。然而,没有就业的数量的类别之间的联系或主要工作和PD的持续时间。在女性中,PD呈正相关,更复杂的工作与人(或= 0.69 (95% CI 0.53 - -0.89)),代表风险增加95% PD比较女性的工作需要最大的复杂性要求最少的复杂性与人一起工作。女性病例也不那么复杂的处理事情与控制(或= 1.45 (95% CI 1.11 - -1.88)),翻译成此风险增加的PD女性工作最复杂的工作比大多数的事情。 The number of jobs and number of job types was associated with taking more activity risks as a young adult.Conclusions: Cases with PD held fewer lifetime jobs compared with controls. Occupational complexity was associated with the risk for PD among women, but not men. Further consideration of the possible influence of personality on occupational choices is warranted.Disclosure: Dr. Borenstein has nothing to disclose. Dr. Sullivan has nothing to disclose. Dr. Wang has nothing to disclose. Dr. Zesiewicz has received personal compensation for activities with Teva Pharmaceuticals as a speaker. Dr. Zesiewicz has received research support from Bobby Allison Ataxia Research Center, National Ataxia Foundation, Astellas Pharmaceuticals, Pfizer, Friedreich's Ataxia Research Alliance, Takeda, Biovail Corporation, Southern Illinois University, and Allon Pharmaceuticals. Dr. Brownlee has received personal compensation for activities with Amylin Pharmaceuticals, Eli Lilly & Company, and Boehringer Ingelheim Pharmaceuticals, Inc. Dr. Mortimer has received personal compensation for activities with Davies, McFarland, and Carroll.Thursday, April 26 2012, 14:00 pm-18:30 pm ER -