@article {WelterS52.005作者={中翻滚,小薇吉妮Czernecki和迈克尔Schupbach和莎拉Fernandez-Vidal Carine卡拉奇,他孤独纳瓦罗和菲利普角和伯纳德Pidoux Luc锤和迪迪埃Dormont玛丽Vidailhet大卫Grabli anne - Marie阀盖和‘被设置和jean - Luc Houeto Eric Bardinet和杰罗姆Yelnik Yves Agid}, title ={为什么双边丘脑下的刺激诱导帕金森患者的认知能力下降{\ textquoteright}疾病?体积(S52.005)} ={78} ={1}补充数量,页面= {S52.005——S52.005} ={2012},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:理解为什么有些PD患者STN-HFS后今年开发了一个认知能力下降。首页背景STN-HFS是有效缓解帕金森运动迹象。然而,一些病人开发手术后认知功能的下降。设计/方法:在02/1996和07/2009,309 PD患者GHPS STN-HFS的操作。手术后患者评估之前和一年:1)神经心理学和精神测试,2)3)帕金森残疾量表(UPDRS部分我VI)。刺激接触得到的精确位置使用一个可调的三维图谱基底神经节。刺激参数和左旋多巴等效剂量被报道。voxel-based-morphometry也进行术前MRI的病人。术后认知功能减退被定义为减少超过1 SD mdr手术后一年和/或mdr \ < 130。PD患者和没有认知能力下降而学生{\ textquoteright}为连续变量s t测试和费舍尔{\ textquoteright}年代精确测试分类变量。结果:二百年54个患者被纳入最后的统计分析。45(21日5 \ %)提出了一个减少mdr超过6分(n = 31)和/或mdr得分低于130 (n = 14)。 No statistical difference in the preoperative clinical characteristics was found between PD patients with vs without postoperative cognitive decline. Patients with postoperative cognitive decline presented a higher rate of postoperative confusion and/or psychiatric troubles. They showed a lower improvement in parkinsonian motor disability and activities of daily living with STN-HFS. The decrease in antiparkinsonian treatment and levodopa-induced complications was not different between the two patients groups. In patients with cognitive decline, the stimulating contacts were located more posteriorly and ventrally, and the frequency of stimulation was lower.Conclusions: STN-HFS may be deleterious for cognitive function, in particular when located in the more ventral part of the STN, thought to process cognitive and emotional information.Disclosure: Dr. Welter has nothing to disclose. Dr. Czernecki has nothing to disclose. Dr. Schupbach has received personal compensation for activities with Medtronic, Inc. and Lundbeck. Dr. Fernandez-Vidal has nothing to disclose. Dr. Karachi has nothing to disclose. Dr. Navarro has nothing to disclose. Dr. Cornu has nothing to disclose. Dr. Pidoux has nothing to disclose. Dr. Mallet has nothing to disclose. Dr. Dormont has nothing to disclose. Dr. Vidailhet has nothing to disclose. Dr. Grabli has nothing to disclose. Dr. Bonnet has nothing to disclose. Dr. Belaid has nothing to disclose. Dr. Houeto has nothing to disclose. Dr. Bardinet has nothing to disclose. Dr. Yelnik has nothing to disclose. Dr. Agid has nothing to disclose. Thursday, April 26 2012, 15:00 pm-16:30 pm}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/78/1_Supplement/S52.005}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }