作者@article {Saint-AubertPD1.006 Laure Saint-Aubert和H = {{} \ ' e l {\ ' e} ne米拉贝尔和C {} \ ' e线Vervueren和帕特里斯P {\ ' e}跑和皮埃尔Payoux与米歇尔Puel Emmanuel Barbeau和弗朗索瓦•Chollet Jeremie Pariente} title ={异构淀粉样蛋白在高度选择概要文件有前驱症状的老年痴呆症患者(PD1.006)},体积={78}={1}补充数量,页面= {PD1.006——PD1.006} ={2012},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目标:我们的目标是确定病人是否满足广告的标准诊断将齐次AV45和CSF淀粉样配置文件。首页背景诊断{\ textquoteright}年代老年痴呆症(广告)是很困难的(Jagust等2007)。国际研究标准已发表改善使用结合临床诊断,地形和physiopathological调查(杜波依斯等人2007)。淀粉样蛋白配体florbetapir (18 f-av45)似乎是有关图像amyloidopathy(克拉克et al . 2011年)。设计/方法:我们招募了16个病人完成了最新的研究标准前驱的广告(Dubois et al . 2007年)。他们都提供下列情景记忆障碍和至少一个标准:内侧颞叶萎缩和/或典型代谢减退在正子扫描和/或典型的脑脊液(CSF)生物标志物水平。所有患者接受了18 f-av45-petscan。对于每个病人,AV45-PETscan与一组16名健康对照组使用z得分。Z得分高于2被认为是重要的。结果:平均年龄是72.8 5.8 {\ textpm}病人4.2和71.2 {\ textpm}控制。2.2意味着MMSE 25.2 {\ textpm}病人0.9和28.3 {\ textpm}控制。 All patients had episodic memory impairment assessed on the Free and Cued Selective Reminding Test (Grober \& Buschke, 1987). Fifteen patients showed medial temporal lobe atrophy and a hypometabolism in temporo-parietal regions. Twelve had a typical CSF profile. Only 10 patients had an AV45 ligand hyperfixation. Among them, 2 had normal CSF biomarkers. Among the 6 patients who were AV45 negative, 4 had a typical CSF profile.Conclusions: Despite a rigourous patients{\textquoteright} selection, only 8 (50\%) had CSF and AV45 profiles congruent with amyloidopathy. Two others had congruent negative profiles that might suggest an amnesic presentation of fronto-temporal lobar degeneration (Hodges et al. 2004). The incongruent profile observed in the the 6 remaining patients are not yet explained and deserve further investigations.Supported by: Sponsored by the Agence Nationale de la Recherche (ANR-08-JCJC-0040) and Toulouse Hospital (2007 N{\textdegree} 07 306 02).Disclosure: Dr. Saint-Aubert has nothing to disclose. Dr. Mirabel has nothing to disclose. Dr. Vervueren has nothing to disclose. Dr. Peran has nothing to disclose. Dr. Payoux has nothing to disclose. Dr. Puel has nothing to disclose. Dr. Barbeau has nothing to disclose. Dr. Chollet has nothing to disclose. Dr. Pariente has nothing to disclose.Monday, April 23 2012, 14:00 pm-18:30 pm}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/78/1_Supplement/PD1.006}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }