RT期刊文章SR电子T1神经心理学相关Logopenic壁萎缩的进行性失语(P02.029)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP P02.029 OP P02.029 VO 78是1补充A1玛丽Machulda A首页1詹妮弗Whitwell A1帕梅拉院长A1杰基米克尔赖特A1约瑟夫·达菲A1 Edythe链A1基思·约瑟夫年2012 UL //www.ez-admanager.com/content/78/1_Supplement/P02.029.abstract AB目的:检查顶叶萎缩之间的关系和视觉空间/ visuoconstructional Logopenic能力进步的失语症(LPA)。背景LPA的特点是受损的单字原图检索和重复的句子和短语。它与左后perisylvian或壁萎缩和低灌注或代谢减退在这些地区SPECT和PET。尽管已知顶叶参与,没有研究到目前为止,研究了视觉空间的功能在这个人口。设计/方法:15受试者年龄在49至83年,招聘作为一个更大的演讲和语言障碍的研究,获得了共识诊断LPA的两个语言病理学家。参与者完成了Rey-Osterrieth复杂图测试(仅Rey-O,复制试验)和视觉对象的多维数据集分析分测验和空间知觉电池(VOSP)。受试者接受了扫描3 t。我们使用SPM5检查Rey-O和VOSP表演之间的关系和灰质体积。结果:低Rey-O表演与灰质体积减少有关在内侧和外侧顶叶和枕叶区域,左>右(p < . 01,富兰克林·德兰诺·罗斯福)。VOSP立方体测试的初始分析显示低表演与顶叶和枕叶区域的灰质体积也会降低双边(左>右)和分散的时间和后额叶区域双边(p <措施,未调整的)。然而,这些发现也没有活下来,修正多重比较(p < . 05,富兰克林·德兰诺·罗斯福)。Conclusions: Cognitive impairment affecting visuospatial function has not been emphasized in LPA. We found that subjects with LPA experience impairment in visuospatial and visuoconstructional abilities that is associated with gray matter loss in posterior brain regions, left greater than right. The stronger findings with the Rey-O may reflect the greater demands that this task places on higher-order visuospatial planning and organization.Supported by: NIH/NIDCD R01-DC010367-02.Disclosure: Dr. Machulda has nothing to disclose. Dr. Whitwell has nothing to disclose. Dr. Dean has nothing to disclose. Dr. Micklewright has nothing to disclose. Dr. Duffy has nothing to disclose. Dr. Strand has nothing to disclose. Dr. Josephs has nothing to disclose.Tuesday, April 24 2012, 07:30 am-12:00 pm