% 0期刊文章%布莱恩Edlow % Emi高桥%一个彼得·卡明斯%约书亚克莱恩%一个Ona吴罗宾·海恩斯% % Steven格林伯格David Greer % %汉娜Kinney %丽贝卡Folkerth % T先进的核磁共振神经网络分析确定外伤性昏迷的解剖基础(in3 - 1.004) % D J神经病学2012% % P in3 - 1.004 - in3 - 1.004 V % 78% N 1补充% X目的:确定一个先进的核磁共振成像技术,高角分辨率扩散成像(现成),可以检测到中断在脑干唤起网络中涉及的创伤昏迷的发病机理。首页背景创伤昏迷被认为是破坏引起的上行网状激活系统(阿拉斯),一个复杂的网络的兴奋从脑干通路投射到下丘脑,丘脑、基底前脑。有一个关键缺乏诊断工具检测哪些组件的阿拉斯网络中断在创伤昏迷。设计/方法:我们使用现成的tractography分析在两个死后大脑神经网络连接:一个62岁的妇女死于创伤昏迷三天后,从一个53岁的女人和一个死于non-neurological原因。标本都是扫描的切割块脑干、下丘脑、丘脑、小口径和基底前脑,高场磁共振扫描仪(4.7特斯拉)。HARDI tractography分析比较每个组件的结构完整性阿拉斯网络的通路在外伤性昏迷和控制标本。在完成成像,标本切片和染色相关组织病理学分析。结果:HARDI tractography透露,阿拉斯网络的特定组件,包括已知的胆碱能和glutamatergic预测连接脑干和丘脑、基底前脑创伤昏迷标本被严重破坏,而正常的标本。这些中断是符合组织病理学组织眼泪和轴突肿胀。相比之下,脑干和下丘脑之间的连接,并在丘脑本身相对保存在创伤昏迷标本。现成的结论:tractography可以检测中断特定组件的阿拉斯网络与创伤昏迷的发病机理。 This advanced imaging technique may be used to elucidate the neuroanatomic basis of coma in individual patients.Supported by: NIH grant R25NS065743.Disclosure: Dr. Edlow has nothing to disclose. Dr. Takahashi has nothing to disclose. Dr. Cummings has nothing to disclose. Dr. Klein has nothing to disclose. Dr. Haynes has nothing to disclose. Dr. Wu has received (royalty or license fee or contractual rights) payments from GE, Siemens, and Olea Medical. Dr. Greer has nothing to disclose. Dr. Greenberg has received personal compensation for activities with Hoffman-Laroche Ltd. as a committee member. Dr. Kinney has nothing to disclose. Dr. Folkerth has nothing to disclose.Monday, April 23 2012, 08:00 am-12:00 pm %U

map