% 0期刊文章%一个黄李文%戴记%大卫·奥尔索普%沙龙Inouye狮子座沃森% %的塔玛拉方% T评估胆碱能和认知功能在健康的年轻成年人使用药物手语灌注磁共振成像(S29.003) % D J神经病学2012% % P S29.003-S29.003 % V 78% N 1补充% X目的:检查胆碱能系统使用药物体内动脉spin-labeling (ASL)灌注磁共振成像。首页背景体内成像的胆碱能功能有可能促进我们理解它在认知的重要作用。药理学磁共振成像,通过检查脑血流量的变化(CBF)药品监督管理局后,可以阐明生理解剖高分辨率影响体内胆碱能调制的认知影响,从而联系到特定的解剖结构。设计/方法:健康的年轻成年人参加了一项随机、安慰剂对照交叉研究(n = 15)。经历了四个药理条件(安慰剂,四甲双环庚胺、莨菪碱、四甲双环庚胺+莨菪碱)在四个独立的日子。手语扫描得到的药物浓度峰值和认知与神经心理学评估电池性能。SPM是用来识别区域的显著改变CBF至少1800像素点的集群。认知能力和重复测量方差分析进行了分析。结果:与莨菪碱、CBF减少双边在丘脑,额叶皮层,补充运动区和增加在枕叶皮质区,中央后回、岛叶、海马、颞极(纠正p值< 0.05)。与结合胆碱能封锁要么单独药物治疗相比,CBF减少在左基底神经节(纠正p值< 0.05)。与安慰剂相比,参与者表现糟糕,内存(选择性提醒测试,p < 0.01)和视觉注意力(与莨菪碱小径B, p < 0.05)。结论:这些结果证实先前发现的减少额和丘脑的灌注和认知赤字与莨菪碱和揭示其他领域涉及认知cholinergically调节血液流动,这表明美国手语可以研究下灌注的变化更加敏感。 The cognitive impairments with cholinergic antagonism, including impaired attention and encoding, are consistent with disruption of the attention network (eg. frontal cortex, supplementary motor area, thalamus, basal ganglia). Likewise memory deficits could result from disruptions of known memory structures (eg. hippocampus) or decreased activity of inhibitory thalamic projections to cortical structures.Supported by: This project was funded by the American Federation for Aging Research Medical Student Training in Aging Research (MSTAR) Program, NIH/NIA grants T35AG038027, T32AG023480, K23AG031320, the Doris Duke Charitable Foundation Clinical Research Fellowship at Harvard Medical School, and the American Academy of Neurology Medical Student Summer Research Scholarship.Disclosure: Dr. Huang has nothing to disclose. Dr. Dai has nothing to disclose. Dr. Alsop has nothing to disclose. Dr. Waterston has nothing to disclose. Dr. Inouye has nothing to disclose. Dr. Fong has nothing to disclose.Wednesday, April 25 2012, 14:00 pm-15:45 pm %U

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