PT -期刊文章Laure Saint-Aubert AU -凯瑟琳赛高特盟盟-凯瑟琳Bezy盟海琳米拉贝尔盟-皮埃尔Payoux盟Herve杜马斯AU -基督教文森特盟帕特里斯Peran AU - Emmanuel Barbeau AU -米歇尔Puel AU -弗朗索瓦Chollet AU -杰雷米Pariente TI失语症在神经退行性疾病:语言障碍可以预测潜在的病理吗?(P02.051) DP - 2012年4月24日TA -神经病首页学PG - P02.051 P02.051 VI - 78 IP - 1补充4099 - //www.ez-admanager.com/content/78/1_Supplement/P02.051.short 4100 - //www.ez-admanager.com/content/78/1_Supplement/P02.051.full所以Neurology2012 4月24日;78 AB -目的:确定临床评估的价值,MRI皮质厚度和[18 fdg) pet代谢在预测病理生理学定义为脑脊液(CSF)的生物标志物的主要语言障碍患者神经退行性来源。背景失语症是常见的神经退行性疾病,可能是主要的症状,如在所有3变种的进步主要失语症(PPA)。一些研究试图预测潜在的病理。每一个变体与占主导地位的组织病理学,但它只能反映集团概率。我们决定考虑潜在的病理(阿尔茨海默病(AD)或non-AD),随后并检查是否有临床、结构或代谢之间的差异可能出现定义组。设计/方法:26失语症的患者接受了全面的语言和神经心理评估,结构磁共振成像,[18 fdg) pet和CSF分析;11的同龄健康对照组(HC)接受同样的考试除了腰椎穿刺。生物标志物在患者CSF允许我们分类广告或non-AD。结果:11名受试者生物标志物与广告相一致,离开15 non-AD组。HC相比,语言障碍是所有患者的主要症状。 However, no differences between groups emerged in language assessments. AD patients exhibit more praxis and visuo-spatial difficulties compared to the non AD group. The difference was significant but less marked for memory. MRI showed more posterior and symmetric cortical thickness reduction in the AD group. No difference in the medial temporal lobe was observed between the two patients groups. Temporo-parietal hypometabolism was more marked in the AD group but no difference in frontal cortex was found.Conclusions: Language impairment is not a reliable predictor of pathology in our patients, though it is the main symptom. Clinical presentation seems to depend on anatomic damage sites more than the underlying pathology.Disclosure: Dr. Sagot has nothing to disclose. Dr. Saint-Aubert has nothing to disclose. Dr. Bezy has nothing to disclose. Dr. Mirabel has nothing to disclose. Dr. Payoux has nothing to disclose. Dr. Dumas has nothing to disclose. Dr. Vincent has nothing to disclose. Dr. Peran has nothing to disclose. Dr. Barbeau has nothing to disclose. Dr. Puel has nothing to disclose. Dr. Chollet has nothing to disclose. Dr. Pariente has nothing to disclose.Tuesday, April 24 2012, 07:30 am-12:00 pm