TY -的T1 -由于神经系统疾病负担在旧病毒阳性和阴性男人:发现艾滋病从多中心队列研究(mac), 1997 - 2009 (P01.257) JF -神经学乔-神经病学SP - P01.257 LP - P01.257六世- 78 - 1补充AU -法拉Mateen AU -罗素筱原尚盟马可•AU - Eric Miller盟贾斯汀麦克阿瑟AU -丽莎·雅各布森盟Ne首页d Sacktor Y1 - 2012/04/23 UR - //www.ez-admanager.com/content/78/1_Supplement/P01.257.abstract N2 -目的:研究神经系统疾病的负担大,老年人群的HIV +的男人与男人性交的男男性接触者(MSM)相比同龄HIV -的时代高效抗逆转录病毒疗法(HAART)。背景人40岁及以上的占了超过四分之一的美国人口生活在艾滋病。艾滋病多中心队列研究(mac)是一个持续的、前瞻性研究的6900多名美国四个城市男男性接触者。设计/方法:我们比较MSM艾滋病+和HIV - 40岁以上总与范畴特定神经诊断负担HAART时代(1997年1月1日持续跟进或死亡,1月1日或之前,2010)。诊断经半年度研究访问,ICD-9从医疗记录链接代码,和死亡证书。泊松回归模型适合科目的人次贡献的时期。结果:总人次MSM超过40岁的风险是27750人年(16013艾滋病毒- 11737 HIV +) 3291人。有163个神经诊断(111 HIV +男男同性恋者在HAART, 22 HIV188金宝慱官网下载 +不是鸡尾酒疗法,艾滋病毒- 30日)在158年40岁以上男性(107 HIV + HAART, 24 HIV +不是鸡尾酒疗法,艾滋病毒- 27日)。Neurological diagnoses were more frequent in HIV+ MSM in the categories of nervous system infections (p<0.001), dementia (p<0.001), seizures/epilepsy (p<0.05), and peripheral nervous disorders (<0.001), but not stroke (p>0.60).Conclusions: HIV+ MSM over age 40 years old have a higher incidence of neurological disease compared to age-matched HIV- MSM. The excess burden is largely accounted for by sequelae of chronic HIV-1 infection in HAART-treated individuals and the persistence of HIV-1 related and opportunistic infections among the diagnosed but untreated HIV+ group.Supported by: Dr. Mateen is supported by the 2010-2012 American Academy of Neurology Practice Research Fellowship Grant. Mr. Russell Shinohara is supported by the Epidemiology and Biostatistics of Aging Training Grant T32 AG000247.Disclosure: Dr. Mateen has nothing to disclose. Dr. Shinohara has nothing to disclose. Dr. Carone has nothing to disclose. Dr. Miller has nothing to disclose. Dr. McArthur holds stock and/or stock options in Gliamed. Dr. McArthur has received research support from Biogen Idec and Pfizer. Dr. Jacobson has nothing to disclose. Dr. Sacktor has nothing to disclose.Monday, April 23 2012, 14:00 pm-18:30 pm ER -