@article {PoliakovP01.044作者={髂骨Poliakov和何塞泰雷兹Zenteno}, title ={疗效和响应预测与迷走神经的神经刺激治疗难治性癫痫:萨斯卡通的经验(P01.044)},体积={80},数量={7}补充,页面= {P01.044——P01.044} ={2013},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:执行一个回顾性分析的有效性和安全性的迷走神经刺激(VNS)难治性癫痫病例在萨斯卡通卫生地区(月)。首页背景:VNS难治性癫痫是一种相对较新的方法。可用不同的设备的数量、各种刺激设置,inter-patient差异和跨中心高可变性的功效已经导致缺乏高质量的数据。此外,手脚的许多机制仍然未知,和体内研究执行主要在动物身上。无论如何,最近的荟萃分析显示,平均而言,大约50 \ %减少发作频率,在耐火材料的情况下。因为这影响并不在所有中心或病人组,结构化审查功效的手脚萎缩不仅可以增加疗效的文献,也协助患者选择这将是最有可能受益于这个过程。设计/方法:创建一个测量仪包括病人的人口统计;其病因;癫痫发作分类;发作频率;抗癫痫药物的使用;和VNS参数,不利影响和有效性。 The instrument will be retrospectively applied to all patients in the SHR who have underwent VNS for the purposes of refractory epilepsy.RESULTS: Of 18 patients, 83\% had generalized epilepsy. A response (\>50\% seizure reduction) was seen in 61\% of our the patients. 83\% of patients reported a reduction in seizure frequency; however, no patients were able to effectively decrease the number of anti-epileptic drugs they were on. All reported side effects were minor and self limiting.CONCLUSIONS: VNS appears to be an effective, and relatively safe, option for refractory epilepsy. Our experience has shown and effect in generalized epilepsy, a group which has been under represented in the literature. Larger retrospective and prospective trials are needed to help predictors of response.Disclosure: Dr. Poliakov has nothing to disclose. Dr. Hern{\'a}ndez-Ronquillo has nothing to disclose.Monday, March 18 2013, 2:00 pm-6:30 pm}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/80/7_Supplement/P01.044}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }