TY -的T1 -识别非典型变种Logopenic进步的失语症(P06.074) JF -神经学乔-神经病学SP P06.074 LP - P06.074六世- 80 - 7补充非盟-玛丽Machuld首页a盟詹妮弗Whitwell AU -约瑟夫·达菲盟Edythe链非盟-帕梅拉院长AU -马修Senjem盟-克利福德杰克盟-基思·约瑟夫Y1 - 2013/02/12 UR - //www.ez-admanager.com/content/80/7_Supplement/P06.074.abstract N2 -目的:本研究的目的是检查失语严重程度和神经认知功能之间的关系,疾病持续时间和颞顶萎缩Logopenic变体的原发性进行性失语(lvPPA)。背景:lvPPA是一种临床综合症,其特征是流利的演讲,在重复语音错误和困难。目前尚不清楚如何言语以外的神经心理功能域和神经影像学异常与失语严重程度和是否代表好的lvPPA疾病进展的生物标志物。此外,目前尚不清楚失语严重程度相关疾病持续时间。理解lvPPA的这些特性之间的关系来确定病人的预后很重要。设计/方法:前瞻性21受试者招募符合lvPPA临床诊断标准。所有受试者完成全面的语言和神经心理学评估)和3 t磁共振成像。失语严重程度是衡量使用西方失语症电池失语商(war AQ)。神经认知全球z分数计算是基于平均从每个认知域z得分。左颞顶皮质的体积测量使用atlas-based分割。两两变量之间的相关性进行了评估,聚类分析用于识别基于war AQ lvPPA亚型和疾病持续时间。结果:有显著性失语严重程度之间的相关性和神经认知程度以及颞顶萎缩,但不是疾病持续时间。 Cluster analysis identified three lvPPA variants: (1) subjects with mild aphasia and short disease duration (mild typical lvPPA); (2) subjects with mild aphasia and long disease duration (mild atypical lvPPA); and, (3) subjects with severe aphasia and relatively long disease duration (severe typical lvPPA). All three variants showed temporoparietal atrophy, with the atypical group showing the least atrophy despite the longest disease duration. The atypical group also showed mild neuropsychological impairment.CONCLUSIONS: We identified a distinct atypical variant of lvPPA with mild aphasia and neuropsychological impairment despite long disease duration, which may represent a slowly progressive variant of lvPPA.Supported by: NIH grant R01-DC010367.Disclosure: Dr. Machulda has nothing to disclose. Dr. Whitwell has nothing to disclose. Dr. Duffy has nothing to disclose. Dr. Strand has nothing to disclose. Dr. Dean has nothing to disclose. Dr. Senjem has nothing to disclose. Dr. Jack has received personal compensation for activities with Janssen, Eisai Inc., General Electric, Johnson & Johnson, and Eli Lilly & Company. Dr. Jack has received research support from Pfizer Inc, Allon, and Baxter. Dr. Jack has received research support from Allon and Baxter. Dr. Josephs has nothing to disclose.Thursday, March 21 2013, 7:30 am-12:00 pm ER -