TY - T1的炎症反应在脑vasoreactivity和认知下降2型糖尿病JF -神经学乔-神经病学SP - 450 LP - 458 - 10.1212 / WNL。首页0000000000001820六世- 85 - 5非盟- Chen-Chih涌盟Daniela Pimentel AU -《j·乔'dan盟应浩盟-威廉Milberg盟事务所维拉诺瓦克Y1 - 2015/08/04 UR - //www.ez-admanager.com/content/85/5/450.abstract N2 -目的:本前瞻性研究的目的首页是探讨炎症之间的关系,脑vasoregulation,认知能力下降在2型糖尿病(T2DM)病人在两年的跨度。方法:六十五名参与者(66±9.2岁,35岁和2型糖尿病,33名女性)为2年的前瞻性研究。连续动脉自旋标记在3-tesla MRI是用来衡量全球和区域脑灌注和vasoreactivity。神经心理措施评估在研究的开始和完成。血清炎症标记物之间的关系、区域脑vasoreactivity,使用最小二乘模型和认知功能检查。结果:经过2年的随访中,参与者与2型糖尿病有减少全球和区域脑vasoreactivity和多个认知任务与基线相比下降(p & lt;0.0001 - -0.012)。通络组,降低脑vasoreactivity与更大的减少日常生活活动得分(r2adj = 0.35, p = 0.04),并降低全球血管舒张与更大的执行功能下降(r2adj = 0.6, p = 0.047)。高血清可溶性细胞间和血管粘附分子,高皮质醇,和更高的c反应蛋白水平基线与更大的减少脑vasoreactivity和血管舒张有关只在2型糖尿病组(r2adj = 0.16 - -0.53, p = 0.007 - -0.048),糖尿病的独立控制和24小时血压。高糖化血红蛋白水平与更大的血管收缩增加2型糖尿病组。Conclusions: Inflammation may further impair cerebral vasoregulation, which consequently accelerates decline in executive function and daily activities performance in older people with T2DM.BMI=body mass index; BP=blood pressure; CASL=continuous arterial spin labeling; CRP=C-reactive protein; HbA1c=glycated hemoglobin A1c; Hct=hematocrit; HVLT-R=Hopkins Verbal Learning Test–Revised; IADL=Instrumental Activities of Daily Living; IL-6=interleukin 6; MAP=mean arterial pressure; MMSE=Mini-Mental State Examination; MP-RAGE=magnetization-prepared rapid-acquisition gradient echo; ROCF=Rey-Osterrieth Complex Figure; sICAM=soluble intercellular adhesion molecule; sVCAM=soluble vascular adhesion molecule; T2DM=type 2 diabetes mellitus; VF=Verbal Fluency ER -