TY - T1的临床和影像学评估急性轻度创伤性脑损伤在阿富汗JF -神经学乔-神经病学SP - 219 LP - 227 - 10.1212 / WNL。首页0000000000001758六世- 85 - 3 AU -屋大维亚当AU -克里斯汀·l . Mac唐纳德AU -丹尼斯铆钉盟-约翰·里特盟-托德可能非盟-玛丽亚Barefield盟乔什·达克沃斯盟-唐纳德LaBarge公司AU -迪恩亚盟本杰明男子AU -伊薇特伍兹盟-迈克尔·康纳AU -大卫·l·布罗迪Y1 - 2015/07/21 UR - //www.ez-admanager.com/content/85/3/219.abstract N2 -目的:评价是非侵入性扩散张量成像(DTI)是否显示白质变化不存在传统MRI在急性blast-related轻度创伤性脑损伤(mTBI)并确定相关临床措施和恢复。首页方法:前瞻性研究的95名美国军人mTBI注册7天内从伤病在阿富汗和101名健康对照组。评估包括Rivermead后震荡症状问卷(RPCSQ),创伤后应激障碍检查表军事(PCLM)、贝克抑郁量表(BDI),平衡误差评分系统(贝丝),自动化的神经心理学评估指标(安南),常规MRI和唯一。观察结果:明显更大的障碍在参与者mTBI vs控制:RPCSQ (19.7±12.9 vs 3.6±7.1, p & lt;0.001),PCLM (32±13.2 vs 20.9±7.1, p & lt;0.001),BDI (7.4±6.8 vs 2.5±4.9, p & lt;0.001)和贝丝(18.2±8.4 vs 15.1±8.3, p = 0.01)。安南性能下降最大的效果是在简单反应时间(mTBI 74.5±148.4 vs控制−11±46.6毫秒,p & lt;0.001)。分数各向异性显著降低在mTBI相比,控制正确的上纵束(0.393±0.022 vs 0.405±0.023, p & lt;0.001)。 No abnormalities were detected with conventional MRI. Time to return to duty correlated with RPCSQ (r = 0.53, p < 0.001), ANAM simple reaction time decline (r = 0.49, p < 0.0001), PCLM (r = 0.47, p < 0.0001), and BDI (r = 0.36 p = 0.0005).Conclusions: Somatic, behavioral, and cognitive symptoms and performance deficits are substantially elevated in acute blast-related mTBI. Postconcussive symptoms and performance on measures of posttraumatic stress disorder, depression, and neurocognitive performance at initial presentation correlate with return-to-duty time. Although changes in fractional anisotropy are uncommon and subtle, DTI is more sensitive than conventional MRI in imaging white matter integrity in blast-related mTBI acutely.ANAM=Automated Neuropsychological Assessment Metrics; BDI=Beck Depression Inventory; BESS=Balance Error Scoring System; DTI=diffusion tensor imaging; FA=fractional anisotropy; FDR=false discovery rate; KAF=Kandahar Airfield; LNK=Bastion/Camp Leatherneck; mTBI=mild traumatic brain injury; PCLM=Post-Traumatic Stress Disorder Checklist Military; PTA=posttraumatic amnesia; PTSD=posttraumatic stress disorder; ROI=region of interest; RPCSQ=Rivermead Post-Concussion Symptoms Questionnaire; SLF=superior longitudinal fasciculus; SRT=simple reaction time; TOMM=Test of Memory Malingering ER -