PT -期刊文章盟-屋大维亚当盟-克里斯汀·l . Mac唐纳德AU -丹尼斯铆钉盟-约翰·里特盟-托德可能非盟-玛丽亚Barefield盟乔什·达克沃斯盟-唐纳德LaBarge公司AU -迪恩亚盟-本杰明男子AU -伊薇特伍兹AU -迈克尔·康纳AU -大卫·l·布罗迪TI -临床和影像学评估急性轻度创伤性脑损伤在阿富汗援助- 10.1212 / WNL。0000000000001758 DP - 2015年7月21日TA -神经病首页学第六PG - 219 - 227 - 85 IP - 3 4099 - //www.ez-admanager.com/content/85/3/219.short 4100 - //www.ez-admanager.com/content/85/3/219.full所以Neurology2015 7月21日;85 AB -目的:评估是否扩散张量成像(DTI)无创显示白质变化不会出现在常规MRI在急性blast-related轻度创伤性脑损伤(mTBI)并确定相关临床措施和恢复。方法:前瞻性研究的95名美国军人mTBI注册7天内从伤病在阿富汗和101名健康对照组。评估包括Rivermead后震荡症状问卷(RPCSQ),创伤后应激障碍检查表军事(PCLM)、贝克抑郁量表(BDI),平衡误差评分系统(贝丝),自动化的神经心理学评估指标(安南),常规MRI和唯一。观察结果:明显更大的障碍在参与者mTBI vs控制:RPCSQ (19.7±12.9 vs 3.6±7.1, p & lt;0.001),PCLM (32±13.2 vs 20.9±7.1, p & lt;0.001),BDI (7.4±6.8 vs 2.5±4.9, p & lt;0.001)和贝丝(18.2±8.4 vs 15.1±8.3, p = 0.01)。安南性能下降最大的效果是在简单反应时间(mTBI 74.5±148.4 vs控制−11±46.6毫秒,p & lt;0.001)。分数各向异性显著降低在mTBI相比,控制正确的上纵束(0.393±0.022 vs 0.405±0.023, p & lt;0.001)。 No abnormalities were detected with conventional MRI. Time to return to duty correlated with RPCSQ (r = 0.53, p < 0.001), ANAM simple reaction time decline (r = 0.49, p < 0.0001), PCLM (r = 0.47, p < 0.0001), and BDI (r = 0.36 p = 0.0005).Conclusions: Somatic, behavioral, and cognitive symptoms and performance deficits are substantially elevated in acute blast-related mTBI. Postconcussive symptoms and performance on measures of posttraumatic stress disorder, depression, and neurocognitive performance at initial presentation correlate with return-to-duty time. Although changes in fractional anisotropy are uncommon and subtle, DTI is more sensitive than conventional MRI in imaging white matter integrity in blast-related mTBI acutely.ANAM=Automated Neuropsychological Assessment Metrics; BDI=Beck Depression Inventory; BESS=Balance Error Scoring System; DTI=diffusion tensor imaging; FA=fractional anisotropy; FDR=false discovery rate; KAF=Kandahar Airfield; LNK=Bastion/Camp Leatherneck; mTBI=mild traumatic brain injury; PCLM=Post-Traumatic Stress Disorder Checklist Military; PTA=posttraumatic amnesia; PTSD=posttraumatic stress disorder; ROI=region of interest; RPCSQ=Rivermead Post-Concussion Symptoms Questionnaire; SLF=superior longitudinal fasciculus; SRT=simple reaction time; TOMM=Test of Memory Malingering