TY - T1的脑炎和AMPA受体抗体JF -神经学乔-神经病学SP - 2403 LP - 2412 - 10.1212 首页/ WNL。0000000000001682六世- 84 - 24非盟和平Hoftberger AU -艾格尼丝·Sonderen盟-弗兰克Leypoldt盟-大卫·霍顿AU -迈克尔Geschwind AU -杰弗里·盖尔芬德盟-奔驰帕雷德斯盟——莉迪亚萨瓦特AU -阿尔伯特Saiz盟Maarten j . Titulaer AU -弗朗西斯克格劳盟约瑟Dalmau Y1 - 2015/06/16 UR - //www.ez-admanager.com/content/84/24/2403.abstract N2 -目的:我们报告的临床特征,并存病,结果22新发现患者抗体α-amino-3-hydroxy-5-methyl-4-is首页oxazolepropionic酸受体(AMPAR)。方法:这是一个病人的回顾性诊断2009年5月至2014年3月。免疫技术已报告。结果:病人的平均年龄是62岁(范围23 - 81;14女)。四个症状识别:12(55%)患者呈现独特的边缘脑炎(LE), 8例(36%),边缘功能障碍以及多病灶的/弥散性脑病,一个与之前勒汽车赤字,和一个与精神病双功能。14例(64%)肿瘤表现出病态(5肺、4胸腺瘤,2乳腺癌、卵巢畸胎瘤)或放射检查肺(1)。额外的抗体发生在7例(3 onconeuronal 1肿瘤,2细胞表面,和1肿瘤和细胞表面),所有与神经症状或肿瘤并发自身免疫反映。治疗和结果可以从21例(平均随访72周,范围5 - 266):5免疫治疗和肿瘤治疗有很好的回应,10部分反应,和6没有改善。最终5患者死亡; all had a tumor or additional paraneoplastic symptoms related to onconeuronal antibodies. Coexistence of onconeuronal antibodies predicted a poor outcome (p = 0.009).Conclusion: Anti-AMPAR encephalitis usually manifests as LE, can present with other symptoms or psychosis, and is paraneoplastic in 64% of cases. Complete and impressive neurologic improvement can occur, but most patients have partial recovery. Screening for a tumor and onconeuronal antibodies is important because their detection influences outcome.AMPAR=α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; FLAIR=fluid-attenuated inversion recovery; IQR=interquartile range; LE=limbic encephalitis; mRS=modified Rankin Scale score; SCLC=small cell lung cancer ER -